Please use this identifier to cite or link to this item: http://dx.doi.org/10.25673/101145
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dc.contributor.authorMichel, Wiebke-
dc.contributor.authorFärber, Jacqueline-
dc.contributor.authorDilas, Milica-
dc.contributor.authorHeuft, Hans-Gert-
dc.contributor.authorTammer, Ina-
dc.contributor.authorBaar, Jannik-
dc.contributor.authorKaasch, Achim-
dc.date.accessioned2023-02-09T13:47:49Z-
dc.date.available2023-02-09T13:47:49Z-
dc.date.issued2021-
dc.date.submitted2021-
dc.identifier.urihttps://opendata.uni-halle.de//handle/1981185920/103102-
dc.identifier.urihttp://dx.doi.org/10.25673/101145-
dc.description.abstractObjectives The optimal diagnostic specimen to detect SARS-CoV-2 by PCR in the upper respiratory tract is unclear. Mouthwash fluid has been reported as an alternative to nasopharyngeal and oropharyngeal swabs. We compared mouthwash fluid with a combined oro-nasopharyngeal swab regarding test performance. Methods In a large refugee facility, we retested individuals with a previous positive test for SARS-CoV-2 and their quarantined close contacts. All individuals were asymptomatic at the time of testing. First, a mouthwash (gargling for at least 5 s) with sterile water was performed. Then, with a single flocked swab the back of the throat and subsequently the nasopharynx were sampled. Samples were inactivated and analysed on a Roche cobas 6800 ® system with the Roche SARS-CoV-2 test. Results Of 76 individuals, 39 (51%) tested positive for SARS-CoV-2 by oro-nasopharyngeal swab. Mouthwash detected 13 of 76 (17%) infections, but did not detect any additional infection. Samples that were positive in both tests, had lower cycle threshold (Ct)-values for oro-nasopharyngeal samples, indicating a higher virus concentration, compared to samples only positive in oro-nasopharyngeal swabs. Conclusion Mouthwash is not as sensitive as combined oro-nasopharyngeal swab in detecting upper respiratory tract infection.eng
dc.description.sponsorshipProjekt DEAL 2021-
dc.language.isoeng-
dc.relation.ispartofhttp://link.springer.com/journal/15010-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subjectDiagnostic accuracyeng
dc.subjectSensitivityeng
dc.subjectSpecificityeng
dc.subjectCOVID19eng
dc.subjectSARS2eng
dc.subjectMouthwasheng
dc.subjectOronasopharyngeal swabeng
dc.subject.ddc610.72-
dc.titleA combined oro-nasopharyngeal swab is more sensitive than mouthwash in detecting SARS-CoV-2 by a high-throughput PCR assayeng
dc.typeArticle-
dc.identifier.urnurn:nbn:de:gbv:ma9:1-1981185920-1031026-
local.versionTypepublishedVersion-
local.bibliographicCitation.journaltitleInfection-
local.bibliographicCitation.volume49-
local.bibliographicCitation.issue3-
local.bibliographicCitation.pagestart527-
local.bibliographicCitation.pageend531-
local.bibliographicCitation.publishernameUrban & Vogel-
local.bibliographicCitation.publisherplaceMünchen-
local.bibliographicCitation.doi10.1007/s15010-021-01600-1-
local.openaccesstrue-
dc.identifier.ppn1779174128-
local.bibliographicCitation.year2021-
cbs.sru.importDate2023-02-09T13:42:39Z-
local.bibliographicCitationEnthalten in Infection - München : Urban & Vogel, 1973-
local.accessrights.dnbfree-
Appears in Collections:Medizinische Fakultät (OA)

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