Study of the Relationship between Heme Oxygenase-1, Interleukins (6, 12) and Coenzyme Q10 in Iraqi Pediatric Patients with Chronic Myeloid Leukemia

Abstract

A global disorder impacted by both genetic and environmental factors, chronic myeloid leukaemia (CML) is associated with increasing mortality and morbidity rates and has social and economic consequences. This particular kind of cancer affects the bone marrow, a spongy substance found in the center of most bones that produces the majority of the body's blood cells, Mossler was the first to describe the bone marrow biopsy technique for the diagnosis of leukaemia. Wilhelm Epstein coined the word "acute leukaemia" to distinguish the rapidly growing and fatal leukaemia from the more indolent chronic leukaemia, myeloid cells, the malignant cell in acute myeloid leukaemia, were identified by Otto Naegeli, who divided leukaemia into myeloid leukaemia and lymphoid leukaemia. The present study was conducted to determine the level of heme oxygenase-1 enzyme and to study and estimate the level of some biochemical parameters such as: interleukins (interleukin-6, interleukin-12) as well as the enzyme coenzyme COQ10 in the serum of patients with chronic myelogenous leukaemia in paediatric patients. The study included (60) patients who visited the Central Children's Hospital in Baghdad Governorate and who were previously diagnosed with chronic myelogenous leukaemia through a complete blood count and bone marrow examination in addition to other tests used to diagnose patients with leukaemia, and (30) apparently healthy people of both sexes in the same age group and considered them a control group. The results showed no significant increase (P<0.05) in the levels of heme oxygenase-1, interleukin-12 and coenzyme Q10 when compared to the control group, but there was a significant difference at the probability level (P<0.05) in interleukin-6 when compared to the control group in patients with chronic myeloid leukaemia in children.