Evaluation of Aqueous Flaxseed Extract on Liver Histological Structure in Diabetic-Induced White Mice

Abstract

This study aimed to evaluate the effectiveness of an aqueous extract of flaxseed on liver histology in diabetic rats. The results of the study showed that the liver of animals induced with diabetes had many histological changes, including the appearance of congestion in the central vein surrounded by hepatocytes that appeared irregular in shape. It was also noted that there was a loss of the radiographic appearance, irregularity in the venous sinusoids, expansion of the liver sinusoids, necrosis in the wall of the central vein, and the appearance of active transport vesicles. Nuclear death was also observed in some hepatocytes, and the cytoplasm of the hepatocytes was necrotic. The study also showed hypertrophy and thickening of the nuclei. Fatty degeneration was also observed with necrosis of the hepatocytes, indicating the occurrence of hepatocyte degeneration and focal destruction. Infiltration of inflammatory cells was also observed. The two groups of animals treated with the aqueous extract of flax seeds at a concentration of 0.2 showed that the central vein was surrounded by more regular cells than in the two previous groups, and that there was less blood congestion in the central vein of the liver. The shape of the venous sinusoids was more regular in most sections, and there was less accumulation of Kupffer cells in them, as well as the disappearance or less decomposition of the nuclei in some liver cells. It was also noted that there was an improvement in the level of radial organization of cells in the liver parenchyma.