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http://dx.doi.org/10.25673/39745| Title: | CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis |
| Author(s): | Pawlitzki, Marc Butryn, Michaela Kirchner, Florian Färber, Jacqueline Beuing, Oliver Minnerup, Jens Meuth, Sven Neumann, Jens |
| Issue Date: | 2019 |
| Type: | Article |
| Language: | English |
| URN: | urn:nbn:de:gbv:ma9:1-1981185920-417004 |
| Subjects: | Primary angiitis of the central nervous system (PACNS) Biomarker Neurofilament light chain (NFL) |
| Abstract: | The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro-axonal damage and arterial-vessel abnormalities was observed with magnetic resonance imaging as well as with MR- and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/41700 http://dx.doi.org/10.25673/39745 |
| Open Access: |  Open access publication |
| License: |  (CC BY-NC-ND 4.0) Creative Commons Attribution NonCommercial NoDerivatives 4.0 |
| Journal Title: | Annals of Clinical and Translational Neurology |
| Publisher: | Wiley |
| Publisher Place: | Chichester [u.a.] |
| Volume: | 6 |
| Issue: | 6 |
| Original Publication: | 10.1002/acn3.790 |
| Page Start: | 1134 |
| Page End: | 1137 |
| Appears in Collections: | Medizinische Fakultät (OA) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Pawlitzki et al._CSF_2019.pdf | Zweitveröffentlichung | 1.45 MB | Adobe PDF |  View/Open |