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http://dx.doi.org/10.25673/86381| Title: | VGF expression by monocytes in patients with Alzheimer’s disease and vascular dementia |
| Author(s): | Busse, Stefan Gregor Meyer, Eva Dobrowolny, Henrik Mawrin, Christian Hartig, Roland Bogerts, Bernhard Busse, Mandy |
| Issue Date: | 2021 |
| Type: | Article |
| Language: | English |
| URN: | urn:nbn:de:gbv:ma9:1-1981185920-883342 |
| Subjects: | Alzheimer’s disease Vascular dementia Monocytes VGF Biomarker |
| Abstract: | Because its secretion is changed in cerebrospinal fluid and peripheral blood, the neuronal polypeptide VGF (nonacronymic) has been discussed as a biomarker for neuropsychiatric disorders. We have shown an enhanced VGF expression by T-cells from Alzheimer’s disease (AD) patients. In this study, we investigated the VGF expression by peripheral monocytes in 38 AD patients, 5 patients with vascular dementia (VD), and 20 neuropsychiatrically healthy individuals using flow cytometry. We determined an enhanced number of VGF-expressing monocytes in VD patients compared to AD patients. VGF+CD14+ monocytes were not correlated with age, body mass index, Mini-Mental State Examination (MMSE), or Q albumin. These preliminary data support findings indicating that VGF might play a role as a peripheral biomarker in VD. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/88334 http://dx.doi.org/10.25673/86381 |
| Open Access: |  Open access publication |
| License: |  (CC BY 4.0) Creative Commons Attribution 4.0 |
| Sponsor/Funder: | Transformationsvertrag |
| Journal Title: | GeroPsych |
| Publisher: | Hogrefe |
| Publisher Place: | Cambridge, Mass. |
| Issue: | 2021 |
| Original Publication: | 10.1024/1662-9647/a000263 |
| Page Start: | 1 |
| Page End: | 7 |
| Appears in Collections: | Medizinische Fakultät (OA) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Busse et al._VGF expression_2021.pdf | Zweitveröffentlichung | 213.98 kB | Adobe PDF |  View/Open |