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http://dx.doi.org/10.25673/120502| Title: | Investigations of anti-infective agents from Camellia sinensis and Kniphofia foliosa and development of a microbiological tool to study antimycobacterial activity under hypoxic conditions |
| Author(s): | Feilcke, Ruth |
| Referee(s): | Imming, Peter Asres, Kaleab Junker, Björn |
| Granting Institution: | Martin-Luther-Universität Halle-Wittenberg |
| Issue Date: | 2025 |
| Extent: | 1 Online-Ressource (IX, 136 Seiten, Seite XII-XXXV) |
| Type: | Hochschulschrift |
| Type: | PhDThesis |
| Exam Date: | 2025-08-12 |
| Language: | English |
| URN: | urn:nbn:de:gbv:3:4-1981185920-1224575 |
| Abstract: | his cumulative thesis focuses on three major communicable diseases in Sub-Saharan Africa: HIV, malaria, and tuberculosis, as well as the global burden of antimicrobial resistance. Secondary plant metabolites of Camellia sinensis and Kniphofia foliosa, both plants that are endemic to or cultivated in sub-Saharan Africa, were investigated for their anti-infective potential. Additionally, a new microbiological assay was designed that can identify compounds that are bactericidal to low-oxygen persisters of Mycobacterium abscessus. This subpopulation of Mycobacterium abscessus is in particular difficult to eradicate, yet it is most relevant in the context of treating non-tuberculous pulmonary infections. |
| URI: | https://opendata.uni-halle.de//handle/1981185920/122457 http://dx.doi.org/10.25673/120502 |
| Open Access: |  Open access publication |
| License: |  In Copyright |
| Appears in Collections: | Interne-Einreichungen |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Dissertation_MLU_2025_FeilckeRuth.pdf | 66.12 MB | Adobe PDF |  View/Open |